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- In silico screening of known small molecules to bind ACE2 specific RBD on Spike glycoprotein of SARS-CoV-2 for repurposing against COVID-19
In silico screening of known small molecules to bind ACE2 specific RBD on Spike glycoprotein of SARS-CoV-2 for repurposing against COVID-19
| Name | World Continuing Education Alliance |
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| Activity Title | In silico screening of known small molecules to bind ACE2 specific RBD on Spike glycoprotein of SARS-CoV-2 for repurposing against COVID-19 |
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| Details | The complete genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is 82% identical to SARS-CoV, both viruses share a common clade encompassing the genus. Drug repurposing is a commercially viable strategy, as it exploits existing drugs, thus significantly reducing the cost and time involved in developing effective therapeutics. Current drugs in different phases of clinical trials are being investigated for inhibitory activity against viral targets that play a significant role in the coronavirus infection lifecycle. The drug targets might be involved in entry into the host (e.g. umifenovir and chloroquine), replication (e.g. lopinavir/ritonavir), or RNA synthesis (e.g. remdesivir/favipiravir). Among these, targeting SARS-CoV-2 cellular entry via the spike glycoprotein (SARS-CoV-2-S) has emerged as the leading option for repurposing. The entry of COVID-19 pathogen is mediated by the homotrimeric transmembrane protein SARS-CoV-2-S. It is comprised of two functional subun... |
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| Competence | Public Health |
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| Start Date | <span class="not-set">(not set)</span> |
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| End Date | <span class="not-set">(not set)</span> |
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| Event Time | 11:15 AM |
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| Location | World Continuing Education Alliance eLearning System |
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| Cost (UGX) | 0 |
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| CPD Points | 1 |
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