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- In silico analysis of natural compounds targeting structural and nonstructural proteins of chikungunya virus
In silico analysis of natural compounds targeting structural and nonstructural proteins of chikungunya virus
| Name | World Continuing Education Alliance |
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| Activity Title | In silico analysis of natural compounds targeting structural and nonstructural proteins of chikungunya virus |
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| Details | Chikungunya virus (CHIKV) is an alphavirus belonging to the Togaviridae family. Studies on antivirals for chikungunya generally target the replication machinery (nsP2 and nsP3 proteins). Alphavirus CP is a multifunctional protein known to act as serine protease for self-cleavage and viral genomic RNA binding. It is also known to bind to other CP molecules during nucleocapsid formation, and interact with viral spike proteins during virion formation and budding. The structural protein E3 is approximately 6KDa, and is found not to be associated with the mature virion. In the present study, we performed an n
Objectives
Course Objective
Chikungunya fever presents as a high-grade fever during its acute febrile phase and can be prolonged for months as chronic arthritis in affected individuals. Currently, there are no effective drugs or vaccines against this virus. The present study was undertaken to evaluate protein-ligand interactions of all chikungunya virus (CHIKV) proteins with natural compounds from a MolBase library in order to identify potential inhibitors of CHIKV.. |
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| Competence | Public Health |
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| Start Date | <span class="not-set">(not set)</span> |
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| End Date | <span class="not-set">(not set)</span> |
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| Event Time | 09:45 AM |
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| Location | World Continuing Education Alliance eLearning System |
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| Cost (UGX) | 0 |
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| CPD Points | 1 |
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